Purchase Best Quality Melanotan 2 Peptide Online for Scientific Research
Melanotan 1 is an injectable peptide that is commercially produced for research and scientific analysis. It is a variant of endogenously produced hormone alpha melanocyte stimulating hormone. Alpha melanocyte stimulating hormone is a crucial peptide as it accentuates production of melanin in the skin epidermal layers. The formation of melanin on the skin is an essential process because it helps prevent uncontrolled multiplication of cells on the skin layer. Melanotan 2 is a biologically synthesized hormone and is classified as a second generation in the alpha melanocyte stimulating hormone. Melanotan 2 was produced after identification of melanotan 1. Researchers from university of Arizona were looking at different aspects of melanin production and how to reduce the occurrence of melanoma.
The alpha melanocyte stimulating hormone is very important in a biological system because it promotes melanogenesis. Melanogenesis is a process where eumelanin or brown pigmentation is converted into melanin in the presence of ultraviolet light. The skin pigmentation process is important because it helps to prevent any uneven epidermal cell multiplication.Uneven or uncontrolled cellular multiplication can cause severe problems such as skin cancer or melanoma. Melanoma is a condition associated with harmful ultraviolet rays. The alpha melanocyte stimulating hormone is essential because it accentuates a signal transduction and the movement of melanotan 2 peptide from the source organ to target organ.
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Alpha melanocyte stimulating hormone works with other signal transmitters in the system to bring about change and cellular division in a biological system. The signaling cascade activates melanocortin receptors located on the skin and this is crucial because it will perpetuate changes on the epidermal skin layer. When these receptors are activated, they have a net positive feedback mechanism on libido, metabolism and appetite. Recent research studies on mice showed that melanotan 2 has a complex signaling system which accentuates production of melanin on the skin alongside other side effects. There are various postulated benefits of melanotan 2 and these include lipolytic properties, suppression of appetite and tanning of the skin. The ability to induce skin tanning without exposure to ultraviolet rays is a major area of interest for researchers.
This is particularly crucial in preventing complications associated with ski-related conditions or cellular multiplication on the epidermis. The study found out that melanotan 2 had a net positive effect in inducing sexual arousal. When the melanotan peptide is injected into male mice, they were sexually active as they showed erections and solicitation behaviors. On the other hand, the female mice showed reddening of the sexual organs and solicitation behaviors. Researchers are looking into different areas for a synthetic peptide that can stimulate endogenous production without exposure to ultraviolet rays or the sun. Melanotan 2 has a molecular formula Ac-Nle-cyclo [Asp-His-D-Phe-Arg-Trp-Lys]-NH2.
The melanotan peptide was discovered by scientists at university of Arizona during their study to find a cure for skin cancer. These researchers stumbled upon afamelanotide, melanotan and later melanotan 1. Advancement in production techniques and accentuated production equipment allowed them to come up with a better peptide melanotan 2. Melanotan 2 has a lower molecular weight which means it can traverse through cells and tissues easily to reach the target organ. The reduction in density and molecular weight of the peptide improved its functionality.
Melanotan 2 and Sunless Tanning
Researchers at University of Arizona synthetically manufacturing a peptide that can cause melanogenesis without the need to expose the skin to too much sunlight. It was through the study that they discovered melanotan 2. The main objective of the study was to find a peptide that can induce sunless tanning without causing a major side effect on the biological system. Focus then shifted to weight and density reduction. Once these two parameters were reduced, researchers would find a peptide that can penetrate cells and tissues easily. A peptide which can penetrate through cells, will reach the target organ easily, reducing the time taken for it to perform a certain function. It was through the study that they came up with melanotan 2. This modern peptide works through various signaling cascades to bring about changes in eumelanin to melanin on the epidermal skin layer. Focusing on the weight of the peptide is crucial because when its weight is reduced, functionality improves and has a net positive effect on half-life and mechanism of action.
Melanotan 2 is made up of seven amino acids in the chain. It is important to note that scientists modified the original linear peptide to melanotan 2 peptide that is circular in conformation . Melanotan 2 works by stimulating the central melanocortin receptors on the skin. This is important in initiating a signaling cascade that accentuates melanogenesis. Research studies showed that administration of the melanotan peptide causes a significant reduction in serum insulin and cholesterol in the test subjects. Nevertheless, the newer melanotan 2 peptide does not have a significant effect on serum levels of acetylcholine. Acetylcholine is an essential component in signal reduction because once the peptide is inhibited, it can delay the transfer of information from one neuron to another. Axon potential is an important aspect in a signal transduction process. Acetylcholine is inhibited by palmitoyl transferase 1 and carnitine. Administering an exogenous peptide to a biological system has a net positive effect in accentuating various components in the system.
The alpha melanocyte-stimulating hormone is a non-selective agonist and it has the affinity to bind to melanocortin receptor 5, melanocortin receptor 1, melanocortin receptor 4 or melanocortin receptor 3. Melanocortin receptors are essential in bringing about a change in signal transduction and melanogenesis process. Other peptides usually bind to all five melanocortin receptors. Melanotan 2 is under research to determine its efficacy in binding to the receptors efficiency and accentuating the release of melanin from the epidermal layers of the skin. Skin pigmentation process is stimulated when the skin is exposed to ultraviolet rays. When ultraviolet rays strike the skin surface, it causes a signal transduction and promotion of metabolic pathways that result in conversion of eumelanin into melanin. There is a wide array of metabolic pathways that are important for melanogenesis to occur on the epidermal layers of the skin.
How Melanotan 2 Works
Melanotan 2 peptide binds to the receptor ligand on the skin and this induces production of adenylate cyclase. When adenylate cyclase is produced, it causes the activation and production of adenosine monophosphate or AMP. AMP activates endogenous enzyme protein kinase A or PKA. This is a crucial enzyme that works in a biological system to activate the phosphate group on the AMP. When the phosphate group of adenosine monophosphate is activated, it binds to cyclic adenosine monophosphate response binding element or what is commonly called CREB. The addition of phosphate to CREB results in binding of cyclic adenosine monophosphate response element to microphtalmia transcription factor gene. When this binding occurs, it activates melanocortin receptor 1 on the skin and this is the main process that promotes skin pigmentation. Tanning process is usually promoted by naturally-occurring alpha melanocytes stimulating hormone and it is beneficial in the system because it prevents melanoma.
Recent studies showed that the melanotan 2 peptide can cause tanning more quickly than the naturally produced hormone and the color achieved is more intense compared to the natural tanning process. Research has shown that melanotan 2 can induce sunless tanning and reports showed that the tanning is more natural and the biological working principle is not interfered in the process. Studies showed that for maximum tanning to occur, the melanotan 2 peptide has to be administered three times in regular dosage in a controlled environment. During the research, the placebo and test animals under investigation should not be exposed to the sun or ultraviolet rays because it will interfere with the research findings.
How Does Melanotan 2 Contribute to Weight Loss?
Melanotan 2 is an effective peptide for accentuating weight loss, according to research done on test organisms. When melanotan peptide is administered on research guinea pigs, it resulted in an altered fatty acid oxidation mechanism. Fatty acid oxidation system is essential because it determines the amount of fats burnt in a biological system. In addition, it reduces the total fats content deposited on the peripheral layers of the skin. Central melanocortin program is important because it determines the amount of food ingested by the test organism and it has an immediate effect on fat deposition on peripheral and visceral organs. There is concrete evidence from research done on mice that melanotan 2 peptide plays a major role in reducing fats deposited on visceral and peripheral organs. Melanotan peptide works by increasing response of the cells to hormone leptin. Leptin is a hormone that controls satiety. When the activation of leptin receptors fail, it results in increased hormonal production and low effect on somatotrophs. Lack of regulation of the melanotan 2 peptide can cause an increase in food intake and this result in excess weight usually deposited on visceral and peripheral organs.
Melanotan 2 and Fatty Acid Oxidation
Fatty acid oxidation is an essential process that helps reduce fat content in an organism. When leptin reception is increased fat burning, mechanism is improved and weight loss achieved. Food intake and homeostasis play a significant role in melanocortin receptor control. Recent research studies on mice showed that the melanocortin system controls overall weight. Administration of melanotan 2 peptide increases response to hormone leptin. This peptide is crucial as it initiates a signaling cascade which contributes to weight loss. Deposition of fats to peripheral organs depends on the sensitivity of receptors to leptin and failure to sense the hormone can result in massive weight gain. On the contrary, melanotan 2 peptide can aid in reducing the net effect by increasing receptor sensitivity to leptin. The biological system responds to the receptor binding to leptin by cutting blood and nutrient supply to the adipocytes or fat cells. When blood and nutrient supply is cut off from reaching the fat cells, the cells will die off and this results in weight loss.
Programmed cellular death or apoptosis occurs and once the cells are dead, they are excreted naturally via mitochondria. Melanotan 2 has a major role in reducing the number of fat cells in the system. It is essential to note that research done on mice was monitored on a daily basis. Melanotan 2 is a modern alteration of endogenous alpha melanocyte stimulating hormone on epidermal layer of the skin. Studies done on mice showed that melanotan 2 has a positive effect in reducing the effects of conditions such as actinic keratosis and polymorphous keratosis, among other skin related conditions. Generation of new epidermal cells is crucial in combating effects of system deterioration. These conditions are present in cells where alpha melanocyte stimulating hormone production is low or the receptors have failed to take up the peptide. Melanotan 2 plays a crucial role by initiating cellular response to the peptide and it presents the receptors with more binding sites, thereby increasing its affinity to the peptide. Studies conducted on mice showed that the melanotan peptide is effective because it mimics the natural system or hormone production.
Melanotan 2 Recommended Dosage
Numerous studies have been conducted using the melanotan peptide and findings largely depend on the dosage. When you are conducting any research, it is important that you consider the dosage and altering it in small amounts will help you ascertain the most effective dosage form. The peptide causes site reactions and fatigue as depicted by mice on research. However, it is imperative that you consider the setting of the research and the components that will facilitate the production of results by the test organisms and placebo. Always go for certified and trusted suppliers for peptide supply. Benchmarking of studies cannot be done with laced peptides. The regular recommended dosage ranges from 2-3 mg and you should have a certificate of analysis as well as purity level of the peptide. Research peptides are supplied in freeze-dried vials and should be kept in a freezer at 2-8 degree Celsius. Always reconstitute an amount enough for one study before going on to the next one. Reconstituting the whole vial will affect peptide quality and reproducibility of the results.