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AOD9604 Peptide

$35.95

Product Description

Buy AOD9604 Peptide Online for Scientific Studies

Adrenocorticotropin hormone  and beta-lipotropin are two compounds produced as a result of cleavage of proopiomelanocortin or POMC on the anterior lobe of pituitary gland. This cleavage is important because it accentuates release of two important components in a biological system. Beta-lipotropin is made up of 90 amino acids. It makes the carbonyl carbon of POMC and functionality of the peptide largely depends on amino acids on its chain. AOD9604 plays an essential role in stimulating secretion of melanin from melanocytes. Beta-lipotropin has four other hormones that are cleaved from its amino acid sequence. These hormones include alpha-endorphin, alpha-melanocyte stimulating hormone, metenkephalin, beta-endorphins and gamma endorphins. Beta-lipotropin is essential in the mobilization of lipids via steroidogenesis and lipolysis. AOD9604  is the synthetic version of this peptide. Beta-lipotropin  is a fragment of the human growth hormone from amino acid 176 to amino acid 191 in the C-terminal. Tyrosine is added to the N-terminal to increase its efficiency and potency in the production of various peptides in the system.

AOD9604 has a higher efficiency and potency than human growth hormone. It has the potential of stimulating anti-lipogenic activities or fats burning process. The fats burning process is crucial in accentuating a wide array of beneficial biological processes. Promotion of lipolysis and inhibition of lipogenesis is an essential aspect in preventing deposition of excess fats in the peripheral and visceral organs of a test subject. Lipogenesis is under scrutiny in modern science. The transfer of excess energy to various organs in the body for storage often results in excess weight gain.

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AOD9604 has a molecular mass of 18200 Daltons

AOD9604 has a molecular mass of 18200 Daltons

AOD9604 has a molecular mass of 18200 Daltons and a molecular formula of C78H123N23O23S2. It is vital to note that it is synonymous with other names such as HGH Fragment 177-191 among others. A synthetic version of the human growth hormone was first synthesized by researchers from Monash University. In this study, scientists from the institution were investigating the fat reduction abilities of growth hormone and it was from this research that they concluded that it was controlled by a tiny part of growth hormone peptide amino acid sequence.

The active region discovered was 177-191 of growth hormone and this is less than 10% of the total size of the peptide. The AOD9604 peptide does not have any significant effect on insulin resistance, growth and development. Its mode of action is via biological mimicry of the human growth hormone. The growth hormone plays an important role in regulating metabolism and has no effect on blood glucose and insulin levels in a biological system. The human growth hormone is important in reducing deposition and storage of fats in peripheral and abdominal fats. This process is crucial because it prevents the deposit of fats and adiposity of the test organism. When apoptosis is initiated, fat cells on peripheral and visceral organs are reduced considerably. A reduction in mass and volume of fats cells in the system is important because most modern research is focused on fats reduction and weight loss. In addition, the AOD9604 peptide initiates a signaling cascade that promotes the burning of fats.

Researchers found out that the short fragment has a higher efficacy and potency in accentuating weight loss without affecting food intake. In addition, AOD9604 does not affect insulin-like growth factor 1 and currently there are studies to determine efficacy and potency of the peptide in lipolysis. Research showed that the AOD9604 peptide reduces insulin production in a biological system. In vivo and in-vitro studies are still underway to determine efficacy and potency in lipolysis or burning of fats. In addition, AOD9604 does not induce production of insulin-like growth factor and studies showed that its functionality depended on informational sequence and leading sequence of the strand. It is imperative to understand that AOD9604 is a region of high accessibility and affinity for proteases and amino acid proline. Proline and other amino acids in the sequence cause conformational change in the cytoplasmic domain of band 3 and acts as a pivot for the two domains.

AOD9604 Mode of Action in Weight Loss

AOD9604 Mode of Action in Weight Loss

AOD9604 Mode of Action in Weight Loss

Research has established that the human growth hormone is an anti-lipogenic hormone. On the contrary, its mode of action is not yet understood and researchers are looking at different uses and biological conformations to find how it works. Lipolytic activity of peptide AOD9604 is under investigations because it has shown to be effective in alleviating various conditions such as obesity in research subjects. It works via induction, modulation and expression of β 3-AR. Moreover, administration of this peptide has shown to have a considerable effect on the functionality of β-ARs. Recent findings indicated that administration of AOD9604 increases the  expression of beta 3-AR located in adipose tissues of the test subject. In brown adipose tissues, administration of AOD9604 peptide is known to increase expression of AOD9604 peptide and contribute to overall weight loss. An increase in the expression of hormone is highly related to the decrease in fat .

Adipocytes are fat cells located in visceral and peripheral organs. It is essential to note that treatment using the AOD9604 peptide is a continued research and findings showed that it enhanced expression of beta 3-AR. Contribution to overall functionality is a key aspect in lean body mass according to findings from research done on mice. A significant amount of weight loss occurs in test subjects that are injected with AOD 9604 peptide in a bacteriostatic environment or using saline water. An absence of AOD 9604 peptide showed an increase in fats mass in the abdominal region. However, injection of the AOD9604 peptide resulted in an immediate decrease of fats mass in the animal test subject. Previous research showed that when mice were administered with the human growth hormone fragment, it resulted in the accentuation of weight loss. The correlation between weight loss and administration of the AOD9604 peptide is directly proportional and more studies are focused on efficacy and potency of the peptide.

Human growth hormone fragment AOD9604 and HGH work in synergy to accentuate reduction of adipocytes in visceral and peripheral organs. Administration of peptide on obese mice indicated that this peptide causes a significant decrease in overall fats cell composition. Adipocytes composition and fat cell multiplication is hampered by the production of lipolytic hormones which largely contributes to weight loss. A gradual reduction in adiposity is essential because it contributes to eventual weight loss and does not require any change in caloric intake. This is very crucial because even with a constant food intake, breakdown of fats cells or lipolysis occurs and the organism loses a considerable amount of weight within a couple of weeks. Research studies indicated that the human growth hormone is beneficial in accentuating weight loss via inhibition of blood and nutrients supply to fats cells. In addition, human growth hormone is anti-lipogenic. Therefore, it does not increase the formation of fats cells.

Dosage of AOD9604

Dosage of AOD9604 Peptide

Dosage of AOD9604 Peptide

One main feature that you should consider when conducting any research is to identify a right dosage for study. Moreover, knowing the dosage to administer to a test subject will help greatly in obtaining right findings according to research objectives . The credibility of results and its reproducibility is a key area in any scientific research. Concentration, mode of administration and mechanism of action play a crucial role in determining efficacy and potency of the peptides. Use of AOD9604 in different laboratory studies and settings should produce results that concur with modern findings backed up with comprehensive research. AOD9604 is mediated by expression of anti-lipogenic gene or activity and β 3-AR is the main lipolytic receptors. Enhancing activity of receptors will accentuate efficacy and functionality of the AOD9604 peptide. Subsequent studies have confirmed that primary lipolytic receptors accentuat release of the growth hormone which is essential in reducing fat cells in peripheral and visceral organs. AOD9604 works via mediation of G-coupled protein receptors of adenylate cyclase which causes generation of cyclic AMP and stimulation of PKA or protein kinase A.

This enzyme plays a vital role in accentuating various signaling cascades in the system to bring about a net positive effect on the release of growth hormone. An addition of phosphate molecules to the lipolytic cascade occurs which is essential for hormone sensitive lipase. In BAT coupling of the functional peptide to β 3 AR and transport chains, these transport chains have an ability to enhance mitochondria to accentuate production of adenosine triphosphate. A change in potential gradient accentuates a movement of ions and energy from the upper side to the lower side, thereby causing energy consumption. Research mice that showed a lack of this important receptor depicted lower fats oxidation and resting energy expenditure. Experiments conducted are backed by data and research analysis which helps scientists to come up with modern findings. AOD9604 plays an essential role in inducing weight loss because of induction of various cells to die off and contributes total weight loss.

Recent research scientific studies showed that there is a quite significant difference in mechanism of β 3-AR on fat cells and external stimuli to relieve fat loss. However, the death of adipocytes is crucial in eventual weight loss. Studies revealed that AOD9604 does not interact with human growth hormone receptors but has a net positive effect on promoting weight loss. There was no effect on epididymal white adipose tissues and expression of beta-receptors on ribonucleic acid. This indicated that the AOD9604 peptide does not target tissues in lean animals but instead focuses on brown adipose tissues of fats cells. However, when the peptide was administered to obese mice, AOD9604 showed an increased activity in increasing weight loss and breakdown of adipocytes in visceral and peripheral organs. On the contrary, a mass of brown adipose tissues reduces greatly with an expression of β3-AR RNA. An increase of the AOD9604 peptide acts as a sensitizer to catecholamines that dissipate heat. Heat dissipation is a mode in which fats cells are killed by cutting blood supply to them. When brown adipose tissues are deprived of nutrients and blood supply, they die off and this in turn increases expression of β3-AR RNA.

AOD9604 and Fat Metabolism

 beta 3-AR receptors

beta 3-AR receptors

Recent research studies indicated that AOD9604 increases expression of beta 3-AR receptors and this is associated with fats metabolism. It is very essential to note that total fats reduction is important in a biological system because the test subject experiences overall weight loss within a short duration. In research, obese mice had a lower level of β 3-AR and when the AOD9604 peptide was administered. The receptor’s affinity increased and led to weight loss via inhibition of food and blood supply to the target adipocytes. The fact that human growth hormone peptide increases expression of genes that accentuate weight loss in obese mice while causing no side effect is a modern area of interest. Scientists are looking to capture the benefits of the human growth hormone in various avenues and scientific research. Studies have revealed that AOD9604 has effects on other compounds in the adrenergic pathways. These include hormone sensitive lipase, signaling proteins and β1-ARs. These compounds are often expressed in adipose tissues and without a proper system to accentuate lipolysis, these cells will contribute to a huge weight gain. In essence, beta-AR system expression in a genetic sequence is important because it largely depends on selective agonist mechanism of action and AOD9604 peptide enhances fats breakdown via up-regulation of gene expression.

Modern Research on AOD9604

Modern Research on AOD9604

Modern Research on AOD9604

Research has been conducted on the efficacy and potency of the peptide AOD9604 in a biological system. It is imperative to note that its administration was the main contributor to weight loss. Treating test mice with a regular dose of the growth hormone showed a significant weight loss and scientists are using this phenomenon to ascertain its mechanism of action, efficacy and potency. AOD90604 presents a probable positive future in fighting obesity since it aids weight loss without a need to affect any other cells in a biological system. Proper identification, administration and monitoring of dosage are important because it helps to prevent cell damage via overdose or over expression of certain genes. In research, obese mice were treated with a standard diet and AOD 9604 peptide administered, results were then monitored. On the other hand, placebos were given the same diet and peptide was not administered. Research showed that plasma glycerol increased when the peptide was administered and this could be attributed to the presence of AOD9604. An increase in plasma glycerol is vital because it means peripheral fats have been broken down.

Additional Information

Weight 0.005 g