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GHRP-2 Peptide

$20.95

Product Description

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GHRP or KP 102

GHRP or KP 102

Growth hormone releasing secretagogues is a small classification of amino acids that play an essential role in accentuating release of growth hormone via induction of somatotrophs in the pituitary gland. The mode of action is via activation of G-coupled proteins which in turn converts the signals to accentuate release of growth hormone. It is important to know that growth hormone is very crucial. Without it, growth and development cannot occur when growth hormone is not released from pituitary gland. GHRP 2 was discovered in the 1990s and it was synthesized as a metenkephalin peptide. GHRP or KP 102 as it is popularly known, does not have any similarity with growth hormone releasing hormone. GHRP 2 is made up of six amino acids in its sequence which is connected via amide bonds. Mechanism of action or working principle of action is through biomimicry or via peptide accentuation or release of growth hormone occurs when the synthetic GHRP 2 is administered to test organism.

Growth hormone releasing peptide 2 increases production of growth hormone from the pituitary gland and it has a mild stimulation to levels of prolactin, cortisol and adrenocorticotropin hormone. GHRP 2 is among the best growth hormone secretagogues in accentuating release of growth hormone from somatotrophs. Recent research studies have revealed that growth hormone releasing hormone accentuates release of growth hormone from somatotrophs. Moreover, studies showed that GHRP 2 has lipogenic properties. Subsequent research showed that GHRP 2 is not related to CJC 1295 and sermorelin in any way. However, it is imperative to note that all growth hormone releasing secretagogues interact with hunger peptide, a hormone known to aid in the release of growth hormone via synergistic interactions. It is imperative to understand that synergy helps increase hormonal production per pulse on somatotrophs by diminishing activities of somatostatin.

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Ghrelin

Ghrelin

Somatostatin is a hormone produced alongside growth hormone from the pituitary gland. Since the peptide is released in pulsatile version, an increase in pulses of somatostatin means a low production of growth hormone and an increase in growth hormone release a low production of somatostatin and vice versa. Reduction in somatostatin activities enhances features of GHRP 2 and ghrelin. Growth hormone releasing peptide 2 is a commercially-produced peptide and it is an analog of growth hormone releasing hexapeptide. GHRP 2 has no effect on cortisol, ACTH and PRL levels in a biological system. When GHRP 2 is administered to a test subject, a natural response is to increase the level of calcium in the system. This also causes an increase in the ghrelin peptide. GHRP 2 is a more effective and potent peptide than GHRP 6 because it has the capacity to produce growth hormone for a long time at a steady pace. A steady release of growth hormones is considered essential in research and development. This is mainly because scientists look at an avenue where results can be obtained with precision and reproducibility with no major deviation.

In addition, GHRP 2 has a longer half-life than any other growth hormone releasing secretagogue and it is under various research and analysis for its efficacy and potency. Laboratory findings indicated that growth hormone releasing peptide 2 has a positive feedback mechanism on insulin-like growth factor 1. IGF-1 increases secretion of growth hormone from the anterior lobe of pituitary gland.  Amplitude per cell depends on the concentration of growth hormone releasing hormone. However, it does not promote the formation of fats in visceral and peripheral organs and there is no activity on appetite and gastric emptying. Ghrelin is a hormone secreted by stomach wall which plays an essential role in stimulating a feeling of hunger. Any system requires nourishment to function at an optimal level and release of growth hormone peptide accentuating growth and development. In a physiological system, the activity of growth releasing factors is often affected at the receptor level. Research showed that modern growth hormone release is mediated by NPY gene and other neurons located in the arcuate region.

Features of GHRP 2

Features of GHRP 2

Features of GHRP 2

Recent studies showed that GHRP 2 functionality on mice induces a boost in production and secretion of genes which accentuate production, secretion and release of growth hormone. The main function of the pituitary gland is to aid in the release of growth hormone. Pituitary gland has important biological processes that it would otherwise paralyze the system if it does not function optimally. Pituitary gland mediates functions such as temperature, growth, pain, blood pressure and homeostasis development, among other essential features. GHRP 2 is essential in promoting an increase in secretion of somatotrophic cells and this is essential in accentuating protein synthesis.  Increase in activity of the peptide is vital to blocking the activity of antagonist somatostatin activity. GHRP 2 plays an essential role in regulating the endocrine system which affects cellular proliferation via transmission on G-coupled protein receptors. Recent studies showed that GHRP 2 could elicit other biological functional features if utilized well for research. It has ability to increase production of insulin growth factor 1 in a biological system. Insulin-like growth factor 1 is also called somatomedin C and is a protein  released in the liver. It plays a major role in repair of muscle cells and tissues. Moreover, GHRP 2 increases calcium ion influx and enhances growth and development.

Role of GHRP 2 on Appetite

It is important to understand that the growth hormone releasing peptide 2 in itself does not increase appetite. However, it induces the release of ghrelin, a peptide that accentuates a feeling of hunger by enhancing gastric motility and gastric emptying. Growth hormone releasing peptide 2 is made up of 28 amino acids in its sequence. These amino acids are produced by epsilon cells located in the pancreas and stomach. GHRP 2 is known to boost the functionality of growth hormone by increasing cellular production of the GH hormone. According to recent research done on mice, GHRP 2 increases food intake by accentuating activities of ghrelin. An increase in food intake is a compensation mechanism that will bring about homeostasis and enhance protein synthesis.

Growth hormone releasing peptide 2 has numerous advantages in a system. According to studies conducted, some postulated benefits include conversion of fats in peripheral and visceral organs into energy. A main feature is that it promotes lean body mass and lowers cholesterol levels in the system. Studies showed that administration of GHRP 2 peptide increases muscle ability to repair, bone density and enhances body’s defense mechanism against invasion by bacteria and other pathogens. Moreover, a current study shows that it increases water retention. Activation of GHRP 2 increases production of ghrelin hormone and it plays an essential role in homeostasis and energy regulation. Studies showed that increase in ghrelin and this played a significant role in increasing anorexia and reducing obesity in mice. GHRP 2 synthetic peptide has enhanced bioavailability and there is evidence that it has an increased potency and efficacy than its predecessor.

Current Research on GHRP-2

Current Research on GHRP-2

Current Research on GHRP-2

Recent research studies revealed that rodents increased food consumption and body weight once GHRP 2 peptide was administered. GHRP 2 peptide plays a vital role in accentuating activities of ghrelin. There is sufficient data to prove that peripheral administration of growth hormone releasing peptide 2 increases food intake, promotes lean muscle protein and myoblastic differentiation. It is imperative to note that GHRP 2 increases production of growth hormone by enhancing amplitude per cell production at the anterior lobe of pituitary gland. Hormonal regulation, food intake, and myoblastic differentiation all play a crucial role in a short term and long term fat storage signaling molecule short term signaling molecule is ghrelin, CCK, and PYY. Leptin and insulin form long-term fat storage signaling molecules. GHRP 2 is important in enhancing production of growth hormone from somatotrophs on anterior lobe of pituitary gland. Hormonal regulation and food intake promote cellular increment of products and other components. Ghrelin is secreted by stomach walls and it is known to act on NPY-AGRP neurons to bring out effects on the arcuate nucleus.

One of the main areas of consideration in research is the mechanism of hormonal circulation and how they reach hypothalamic neurons. Studies on rodents showed that centrally administered ghrelin usually acts on the growth hormone secretagogue and it enhances food intake. There is sufficient evidence that GHRP 2 promotes spontaneous variation in endogenous amounts of ghrelin and this has a role in diurnal meal times. Moreover, postprandial suppression of ghrelin is equivalent to a single meal taken. Scientific research data indicates that GHRP 2 and ghrelin has anorexic properties that can cause acute food consumption on the test subject. Although conclusion has not been made on, the efficiency of GHRP 2 results indicates that this peptide could present a modern avenue for further research and conclusion on benefits of the peptides. Alteration of ghrelin increases downstream effect via peripheral and nervous receptors. Recent research studies showed that GHRP 2 peptide might be used to treat various conditions in future after the conclusion of various study reports. However, it is imperative to note that currently peptide in the market is solely for research purposes and human consumption is not allowed.

Administration of GHRP 2

Administration of GHRP 2

Administration of GHRP 2

Growth hormone releasing hormone plays an essential role in promoting cellular division, development and maturity. This process is very crucial to the growth of bones and regeneration of dead or injured cells. Research on mice showed that administration of GHRP 2 caused activities on somatotrophs by increasing cellular production of the peptide. Moreover, findings indicated that the mode of administration plays a crucial role because peptide degradation and efficacy is reduced when exposed to enzymes and other biological components that will deteriorate the potency of GHRP 2 peptide. It is because if scientists are looking for modern ways to accentuate release of hormones and to find the right avenue to deliver the hormone. Sub mucosal delivery is the best route because it is absorbed immediately and is not subjected to temperature and compositional change. The mucosal membrane is ultrathin and it is highly vascularised therefore the peptide will enter into the system without degradation, unlike other modes. Compounds present in the system play a role in reducing the potency of GHRP 2. It is essential that you pick a mode that will deliver optimal result.

GHRP 2 Blends

GHRP 2 Blends

GHRP 2 Blends

GHRP 2 peptide has a higher potency when administered alongside other peptides. CJC 1295 is a commercially produced peptide that mimics the activity of growth hormone releasing hormone production from the anterior lobe of pituitary gland. Sermorelin has shown to increase growth hormone pulses per cell while reducing the pulses of somatostatin. Growth hormone releasing peptides (GHRPs) and ghrelin were discovered in the early 1980s and modern science showed that blends increase efficacy and potency of peptides by exposing more binding sites for receptors to bind to the ligand. Scientific studies led to generation of the first secretagogue and this was referred to as GHRP 2. CJC 1295 and GHRP 2 are closely related and the main function is via activation of ghrelin hormone. Ghrelin increases energy consumption, gastric motility, gastric emptying, and a feeling of hunger. A positive feedback mechanism in stimulating release of growth hormone from the anterior lobe of the pituitary gland is essential because it increases peptide activity.

A combined vial has been shown to enhance peptide activity by increasing potency and effectiveness and a larger pulse or amplitude per cell is seen while maintaining an optimal level of the hormone. Studies revealed that GHRP 2 enhanced lipolysis and inhibits the formation of fats cells in the peripheral and visceral organs. Synergistic functions of GHRP 2 and CJC 1295 are crucial in enhancing hormonal production per cell. The function of cells cannot be underestimated and researchers are looking for avenues to enhance its production and alleviate conditions related to growth hormone production. Scientists are looking for ways to blend various amino acids and peptides to accentuate their functionalities and improve efficacy. It is imperative to note that peptides often come with the different working systems and increasing a pattern will have a net positive effect on the other production.

Additional Information

Weight 0.005 g