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Hexarelin Peptide

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Buy Hexarelin Peptide Online – Powerful Growth Hormone-Releasing Synthetic Hormones

Hexarelin Peptide

Hexarelin Peptide

Hexarelin acetate or simply hexarelin, is a chemically synthesized hexapeptide classified under the growth factor family because of its activity to stimulate secretion of growth hormones. The stimulation by hexarelin does not affect the body’s own mechanism of producing growth hormones. The structure of hexarelin is similar to that of growth hormone hexapeptide or GHRP-6. However, it has no effect on the level of Ghrelin. Ghrelin is a hormone responsible for inducing quick gastric emptying and increased appetite.

Hexarelin is a synthetic growth hormone secretagogue and is made up of 6 amino acids. It is one of the most powerful growth hormone-releasing synthetic hormones. Studies on hexarelin have revealed that the polypeptide reduces visceral and peripheral fats. Just like any other growth hormone-releasing peptides, hexarelin is very effective when administered synergistically with modified GRF, Sermorelin and other growth hormone releasing hormones.

Increasing the circulation of growth hormones via the use of hexarelin is known to increase the levels of insulin-like growth factor 1 (IGF-1) in the liver. IGF-1 is responsible for causing muscle growth and GH stimulation. The molecular mass of the hexarelin polypeptide is 887 Daltons and it has fat loss effects as well. Hexarelin has shown to be effective within 30 minutes which is the half-life of the compound and it induces a rapid secretion of the GH hormone. It helps children grow into adults, maintains muscles and fats burning.Hexarelin peptide is a synthetic hormone which activates the growth hormone secretagogue receptor or GHSR, a similar analog to Ghrelin. Research showed that the peripheral distribution of GHSR in blood vessels and heart indicated that hexarelin may have a direct effect on vascular actions apart from inducing hormonal release as well as neuroendocrine effects. Moreover, the non-GHSR CD 36 has been known to be a receptor specific to the cardiac region. Compared to Ghrelin, hexarelin is more functionally stable, has high potency and is effective. Hence, it is a promising therapeutic agent for most cardiovascular conditions.

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Growth hormone secretagogues or GHS is a class of minute synthetic peptides known to stimulate production and release of growth hormones from the anterior lobe of the pituitary gland. They work by binding to the growth hormone receptor 1a. In addition, the GHSR 1a is a G-protein coupled receptor that was identified to be located only in the pituitary and hypothalamus. However, it was later identified as a receptor for the endogenous hormone Ghrelin. For Ghrelin and GHS, there have been reports that they participate in numerous orexigenic properties on the gastrointestinal tract, fat metabolism, cardiovascular and immune system, among other areas.

Cardiac Action of Hexarelin

Cardiac Action of Hexarelin Peptide

Cardiac Action of Hexarelin Peptide

Earlier studies revealed that Ghrelin administration could help i improve the cardiac functionality in mice and guinea pigs with heart failure. Left ventricle ejection infarction improved when the peptide is administered. In rodents’ myocardial infarction or MI, Ghrelin administration reduced mortality, prevented malignant arrhythmias, improved left ventricle dysfunction and attenuated remodeling of subacute phase. However, Ghrelin is unstable, therefore limiting its use. GHS hexarelin is a chemically-stable compound and is a potent synthetic hexapeptide. It can be administered orally as an alternative to Ghrelin and its effects lasts longer than Gherlin. The half-life of hexarelin is longer than that of Ghrelin. Although studies indicated that cardiac activity of hexarelin is mediated by GHSR 1a and the activation of the CD 36 receptor on smooth muscles of the heart.

Inhibition of Apoptosis

Inhibition of Apoptosis

Inhibition of Apoptosis

When neonatal rat cardiomyocytes were treated with hexarelin, the levels of angiotensin II diminished, thereby inducing DNA fragmentation and apoptosis as well as an increased myocytes viability. Hexarelin treatment has shown to have inhibitory effects on doxorubicin-induced apoptosis and it promoted the survival of endothelial cells and H9C2. The cardio protective effects of hexarelin can be elucidated in its endothelial cells and anti-apoptotic activity. Moreover, when administered, hexarelin is known to induce pathological remodeling, alleviate left ventricle dysfunction and cardiac cachexia in mice. In rats with congestive heart failure, it suppressed activation of stress and cardiomyocytes apoptosis.

Ischemia Reperfusion Injury

Hearts of mice were subjected to a 30-minute followed by 120-minute reperfusion. Hexarelin reduced the size of the infarct which was determined by the use of triphenyltrazolium chloride staining. The protection provided by hexarelin was reduced by the activity of protein kinase C inhibitor chelerythrine.A treatment with hexarelin inhibited cardiomyocytes apoptosis, preserved electrophysiological properties of cells and promoted cell survival through modification of mitogen-activated protein kinase pathways. Moreover, it induced a positive inotropic effect on ischemic cardiomyocytes. According to research, test rats that were treated with hexarelin had their left ventricle pressure built up effectively and the cells were not damaged. The administration of the peptide gave protective effect against post-ischemic ventricular dysfunction and hyperactive responsiveness of the coronary bed to angiotensin II.

Cardiac Fibrosis

hexarelin treatment increased the level of metalloproteinase -9 & -2

hexarelin treatment increased the level of metalloproteinase -9 & -2

Hexarelin treatment of spontaneous hypertensive rats for 40 days mostly reduced cardiac fibrosis through reduction of myocardial collagen deposition and interstitial collagen, reducing myocardial hydroxyproline content and collagen III and I messenger RNA while expression the protein. Moreover, hexarelin treatment increased the level of metalloproteinase -9 and -2 activities while reducing myocardial messenger ribonucleic acid expression of tissue of metalloproteinase-1. Treatment of cultured cardiac fibroblasts with hexarelin inhibited the activities of angiotensin II- induced proliferation, collagen synthesis and transformation of growth factor-beta induced deoxyribonucleic acid synthesis as well as reduction of angiotensin II-mediated up-regulation of TGF-beta release and expression.

Anti-Atherosclerotic Activity

Anti-atherosclerotic activity of hexarelin is observed in adult Sprague-Dawley rat. The rats were treated with hexarelin and this suppressed the formation of atherosclerotic plaques and neointima. Moreover, it partially reversed serum low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio. However, there was an increase in serum nitric oxide levels and the expression of messenger ribonucleic acid of the enzyme nitric oxide synthase, CD 36, GHSRs in the test subjects. Moreover, a treatment with the hexarelin peptide decreased the level of tritiated thymidine incorporated into the cultured vascular smooth muscle cells, foam cell formation induced by the low-density lipoprotein and calcium sedimentation in the aortic wall. In addition, the treatment with hexapeptide did not have any significant effect on triglyceride levels. However, it lowered plasma concentration of cholesterol in obese rats.

Cardiac Receptors

The cardiovascular activities of hexarelin are largely dependent on growth hormone which occurs via the activation of cardiac receptors. Earlier studies have shown that the effects of the peptides are not shared by the growth hormone-releasing hormone or the human growth hormone. This indicated that they are not mediated by any increase in the level of growth hormones. The hexarelin peptide exerted an increase in LVEF and prevented cardiac damage after the ischemia-reperfusion.

Mechanism of Action of Hexarelin

The mechanism of action of hexarelin is not fully understood by researchers However, this is one peptide that can act on the hypothalamus and pituitary glands. Moreover, it can marshal the release of higher amounts of growth hormones than any other growth hormone releasing peptide.

Mechanism of Action of Hexarelin

Mechanism of Action of Hexarelin


Studies revealed that some hexarelin side effects include an increase in mitosis, increase in bone mineral density, meiosis, connective tissue, improved skin elasticity and fat loss. The benefits of the peptide include an increase in lean body mass, fat reduction, anti-ageing properties and an increase in bone density. However, hexarelin side effects include an increase in prolactin levels, decreased libido, possible gynecomastia and increased cortisol levels.

Hexarelin can be administered subcutaneously to the test subject and it activates the pituitary through a pulse in a similar manner to GHRP-6. This helps in circulating the hormone to various parts of the body. The peptide has vital side effects that are useful to any organism. It blocks the activity of somatostatin, a hormone that is released in pulses alongside growth hormone. When the level of somatostatin is decreased, the level of growth hormone release is enhanced. The more growth hormones,the better the health levels of insulin-like growth factor 1. The potency of the hexarelin peptide cannot be underestimated because it is ranked as one of the best growth hormone-releasing peptides.

Hexarelin is delivered as dried powder just like any other growth hormone hexapeptides. The storage of the peptide should be in a cool dry place and reconstituted in a refrigerator. Bacteriostatic water should be used when conducting research or injecting into test samples. Research showed that a combined vial of the hormone and another growth hormone-releasing peptide has an enhanced potency, effectiveness and efficacy.

Cardioprotective Effects of Ghrelin

Cardioprotective Effects of Ghrelin

Cardioprotective Effects of Ghrelin

Hexarelin is a compound that is studied as a ghrelin mimetic and it is the latest potent growth hormone-releasing secretagogue. In addition, it is seen to have an insignificant effect on cortisol and prolactin release. Research has shown that hexarelin is more potent in producing growth hormones from the pituitary gland than any other growth hormone secretagogues. Effects of hexarelin on cortisol or prolactin release depend on the concentration and amount administered in a setting. All ghrelin mimetic are known to have different ways of increasing production of growth hormone from tiny cells on the pituitary gland. It is essential to understand that growth hormone is produced in a pulsatile manner alongside hormone somatostatin. Somatostatin is an antagonist of growth hormone, when somatostatin is produced in high amounts,growth hormones are produced in low amounts and vice versa. The main aim of research and development that is currently in the market focuses on improving efficacy and potency of hexarelin peptide while reducing effects of somatostatin.

Recent research showed that hexarelin has the ability to reduce the extent of cerebral cortex injury and hippocampus after instances of hypoxia-ischemia. This study was done on neonatal mice or tiny mice that were growing up. In addition, ghrelin may have a role in accentuating release of growth hormone from different cells in a biological system. All growth hormone releasing peptide have antioxidant features and it activates GHS-R type 1a cells. These are cells that are located on Sertoli and Leydig cells. It is imperative to know that anti-inflammatory and antioxidant properties of hexarelin are important for cardiac cells. Rejuvenating cardiac cells is essential for optimal functioning of the heart. This is usually achieved by three antioxidant principles superoxidase dismutase, glutathione peroxidase and catalase enzymes. These enzymes are crucial in accentuating oxygenation of various biological system components.

The mechanism of action of hexarelin is not yet fully understood. However, there are studies underway to understand its functionality and it shows that it acts on pituitary somatotrophs. Moreover, the presence of hexarelin in a system increases growth hormones released per cell. The activity on somatotrophs is crucial because it reduces somatostatin pulses while increasing that of growth hormone. Studies show that hexarelin plays a major role in increasing mitosis, meiosis, bone mineral density, skin elasticity and accentuating fat loss.

Postulated benefits of hexarelin include an increase in lean body mass, bone density and alleviating aging cells or improving anti-ageing properties of cells in the system. Hexarelin increases libido in mice as they show lordosis, solicitation, erection and reddening of sexual organs. Hexarelin is supplied as a freeze-dried vial and it is imperative that you monitor the integrity and purity of the peptide before purchasing it. Reconstitution should be made with saline or bacteriostatic water. This is an important part in any research because accuracy is key in research. The addition of any viable microorganism will affect peptide production and results of the study. Benchmarking of studies follows a tight protocol and individuals doing research should follow strict guidelines when using peptides.  Hexarelin is a growth hormone-releasing secretagogue that is gaining popularity for its postulated benefits. However, research is still underway to determine its efficacy and potency.

 

Additional Information

Weight 0.005 g