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Melanotan 1 Peptide

$34.95

Product Description

Purchase Highest Quality of Melanotan 1 Peptide Online

Melanotan 1 is a synthetically manufactured and an alteration of the endogenously produced hormone, the alpha melanocyte-stimulating hormone. Alpha melanocyte stimulating hormone is a very essential hormone that plays an important role in the production and secretion of alpha melanocyte-stimulating hormone from the pituitary gland. Lack of the hormone, low production or lack of sensitivity to the hormone by the receptors result in poor production or lack of production of melanin. Melanin is an essential component in preventing development of skin cancer or carcinoma. The compound forms a complex network of molecules in the epidermal layer of the skin and this traps harmful ultraviolet rays of the sun. The mode of action of the peptide is through mimicking of the biological system production of the alpha melanocyte-stimulating hormone. When the hormone is produced, it targets the epidermal layers of the skin. Tanning process or melanogenesis refers to the conversion of eumelanin to melanin in the skin.

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Without the presence of alpha melanocyte stimulating hormone, the body is unable to synthesize melanin and this leads to exposure to harmful UV rays. It is imperative to note that melanotan is totally different from melanotonin, a molecule that controls sleeping patterns and circadian rhythm. Melanotan is important in the conversion of eumelanin to melanin in the skin and this compound plays a crucial role. Melanotan 1  is under research for its potential benefits in alleviating some conditions such as carcinoma. The peptide has numerous unique features which contributes to its efficacy and potency. Researchers at the University of Arizona discovered the peptide during their study when they were looking for a skin cancer cure.

Melanotan 1

Melanotan 1

How Melanotan 1 Works

Alpha melanocyte stimulating hormone works by stimulating the melanocytes or the cells that produce melanin on the epidermal cells. Moreover, the hormone is synthesized in other parts of the biological system such as the pituitary gland and hypothalamus. The MSH stimulates a wide array of hormones and not one as many people might think. Exposure to ultraviolet rays of the sun triggers production of the melanocyte-stimulating hormone on the epidermal layers of the skin. The MSH is essential in adding pigment to the hair and eyes. The melanotan 1 peptide works by inducing the cells to produce melanin or melanocytes. This process cannot take place without exposure to the sun. When the skin is exposed to the sun, eumelanin is converted into melanin and the melanin causes skin pigmentation. Melanin is a vital component for the biological system because it has protective qualities. It protects epidermal cells and deoxyribonucleic acid from undergoing changes which could cause adverse effects.

Any alteration to the genomic sequence causes effects. In some cases, it results in presented multiplication of cells on the skin. When cellular multiplication cannot be controlled on the skin, it results in skin cancer. Research showed that melanotan 1 is important in inducing self-tanning. This involves the conversion of eumelanin to melanin without exposure to the sun. The peptide plays an important role in maintaining melanin in the biological system and prevents harmful effects of the ultraviolet rays.

Melanogenesis

melanocyte-stimulating hormone

melanocyte-stimulating hormone

Melanotan 1 is an analog of the alpha melanocyte-stimulating hormone and is classified as a melanocortin hormone. Since it is classified as a melanocortin hormone, this type of peptides is known to have influence on skin pigmentation, hair color and sexual arousal, among other unique features. The production of melanin in large quantities is essential for the conversion of eumelanin to melanin on skin cells. The peptide was initially called afamelanotide, it was later called melanotan or melanotan 1.

During the research study, researchers were looking for a peptide that can induce sunless tanning. The focus was on the endogenously produced hormone, alpha melanocyte-stimulating hormone. It was in this study that melanotan 1 was discovered. Findings from the research showed that the synthetic version is a thousand times more potent than the natural hormone.

Melanotan 1 mechanism is via triggering a wide array of signaling cascades that leads to activation of melanocortin receptors. These receptors are essential because they trigger the release of melanotan from the melanocytes on the epidermal layers of the skin. The binding of the peptide to the melanocortin receptor 1 on the epidermal layer, this then causes reactional change which results in the production of eumelanin. In such a case, the eumelanin, a brown or black photo protective pigment, is activated. The activation of the pathway leads to generation of melanin on the skin. This is a complex pathway and once it is activated, melanotan binds to receptors, resulting in the production of adenylate cyclase. Activated adenylate cyclase causes the production of cyclic adenosine monophosphate or cAMP. The compound is important because it results in the activation of PKA or protein kinase A.

Activation of protein kinase A causes an induction and activation of a phosphate group on the adenosine monophosphate. This process is important because it causes the addition of a phosphate group to the CREB or cyclic adenosine monophosphate response elements. When the phosphate group is added to the molecule, it binds to the microphtalmia transcription factor gene. The binding is essential because it causes the production of the MITF protein. MITF gene is important in the activation of various receptors, including the melanocortin 1-receptor genes. The melanocortin 1-receptor genes play an important role in melanogenesis.

Mode of Administration

 melanotan 1 peptide is delivered via intramuscular injection

melanotan 1 peptide is delivered via intramuscular injection

In most scientific research studies, the melanotan 1 peptide is delivered via intramuscular injection. The injection can be delivered in other ways depending on research objective or dosage. In some instances, it can be subcutaneous, intravenous or intramuscular injections. The peptide has 30-60 minutes half-life and this is according to a recent study on mice. It is important to note that melanotan 1 peptide is supplied in vials and should be used in a sterile environment to avoid contamination or bacterial infection.

Possible Side Effects of Melanotan 1

Melanotan 1 is efficient in inducing skin tanning or accentuating the conversion of eumelanin to melanin on the skin. However, the peptide has shown quite a few side effects and they are mostly mild. One side effect is the slow development of the tan which can take weeks depending on the experiment and test subject. Another side effect is  inflammation of the injection site and nausea, among other side effects. Freckles on the skin or flushing in some cases are one of the common side effects of melanotan 1 peptide.

Melanotan 1 Efficacy

Melanotan 1 Efficacy

Melanotan 1 Efficacy

Melanotan 1 is a commercially produced synthetic version of the alpha melanocyte-stimulating hormone and is produced on the pituitary gland. Research showed that the peptide has other effects apart from inducing the production of melanin on the skin. Studies conducted on research mice showed that injection of the peptide caused an increase in appetite, sexual arousal and enhanced libido. Once melanotan is injected, the mice increased food intake. The placebo did not experience any changes in food intake. Moreover, female mice showed solicitation behaviors and began seeking the males. On the other hand, the male mice experienced lordosis and erection of sexual organs. Potency and efficacy of the melanotan peptide is still under research, so the peptides sold in the market are solely for research purposes. When the epidermal layer of the skin is exposed to ultraviolet rays of the sun, some sides effects include actinic keratosis and polymorphous eruptions. These side effects are characterized by dry growths, severe sores, lumps, lesions, patches and burning sensations.

In most scenarios, the results observed showed that melanotan 1 peptide causes results unless the receptors have failed to respond to the administration of the peptide or the peptide itself is produced in very low quantities. An increase in the level of the alpha melanocyte-stimulating hormone in the system increases melanogenesis. This process is crucial in accentuating the functioning of a biological system. Research showed that the receptors and melanocytes can be activated via induction of an external stimulus. This is a new development in which scientists are looking at different methods of using melanotan 1 peptide to accentuate various hormonal productions. Experiments are conducted mostly on mice and guinea pigs. This is essential because their biological systems mimic the natural production in humans.

Sunless tanning is a new principle that has attracted many researchers. It is imperative to note that the process of skin pigmentation is accentuated by exposure to ultraviolet rays of the sun. Recent studies showed that the injection of melanotan on the test subject did not even cause tanning. The half-life and distribution of the melanotan 1 peptide plays an important role because it determines the distance traveled by the peptide in a biological system and the mode of action in various organs.

Melanotan 1 Recommended Cycle

Recent studies revealed that the administration of melanotan 1 via injection caused several side effects on the test subject. Some side effects include fatigue and site reactions, among others. However, it did not change blood hematological and chemistry. It is essential to take into consideration that when conducting any research study using melanotan 1 peptide, you should always look for all these factors before you can purchase it from online vendors. Purchasing melanotan 1 peptide from a certified vendor is essential because the results obtained in the experiments will be of a certain degree of reproducibility and accuracy. There are unscrupulous individuals who include other additives such as mannitol into the peptide and affects its integrity and functionality. When a peptide is laced with other additives, using it for research will cause a huge variance and standard deviation will be above the recommended limits.

Melanotan 1 Dosage Form

Melanotan 1 Dosage Form

Melanotan 1 Dosage Form

Findings from subsequent research indicated that melanotan 1 could be used for an extended period before you can attain results. Dosage administered may vary depending on the species. However, the most recommended dosage is usually 2-3 mg, and depending on the level of activation of these products on melanin on the skin, its dosage may be adjusted. It is imperative to note that when the maximum limit is reached, it cannot affect accentuation or release of the melanotan 1 peptide from the anterior lobe of the pituitary gland. Any addition of dosage to test organism will not cause any significant result or change.

Melanotan is supplied as a freeze dried vial or lyophilized powder and is sealed for multi-purpose uses You should understand that melanotan 1 is susceptible to changes in temperature, pressure and other factors. Any changes in these parameters will result in changes in the amino acid sequence and conformation of the protein. Any further addition of melanotan 1 will not cause any significant effects or changes to the test subject because the optimal production of the pigment has been reached.  The peptide should be transported in an ice pack and the parameters monitored carefully. For research purposes, it is imperative not to underestimate the effects of a parameter change on the overall result.

When conducting research, it is important that you keep the vial in a freezer. During preparation, you should use saline or sterilized water. You can use 1ml of the melanotan 1 peptide to 5m of saline water or 10 ml of bacteriostatic water depending on the dosage you want to formulate. Concentration of the peptide is dependent on the amount of water used in the reconstitution process. When you want to prepare, say 5mg/ml, then you should use 5ml of saline or bacteriostatic water to 1ml of melanotan 1 peptide. The concentration of the research peptide should vary considerably as it gives you a chance to play with various concepts and come up with a conclusion. Further research studies are being conducted to determine the efficacy and potency of melanotan 1 and it is essential that you get a high quality and certified peptide for research.

Additional Information

Weight 0.005 g