Get PT-141 Peptide Online- A Popular Peptide Having Great Latent Qualities
Bremelanotide PT-141 is a synthetic biopeptide of the naturally occurring alpha melanocyte stimulating hormone or alpha MSH. Alpha melanocyte stimulating hormone is essential in boosting the body’s mechanism to cope with appetite, lipid metabolism and libido. PT 141 is a derivative of Melanotan 2. However unlike its predecessor, it does not contain carbonyl amine molecules. The peptide is cyclic and is made up of seven amino acids. It is a lactam or what scientists call lactam derivative of the alpha melanocyte-stimulating hormone.
Principle of Action of PT-141 Bremelanotide
The PT-141 peptide functions by stimulating melanocortin receptors located in the CNS or central nervous system to release the hormone. This polypeptide has the potential of growing to be a popular peptide in research. Moreover, it could be used to treat sexual disorders such as erectile dysfunction in males and arousal disorders in females. The polypeptide has a molecular mass of 1025 Daltons and is not a vasoactive compound. On the contrary, it acts directly on the central nervous system to enhance sexual activity.
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In the past, there have been numerous studies on using the peptide to treat sexual dysfunctions and other conditions. The peptide work as an agonist of the melanocortin peptide hormone, widely known to activate receptors such as MC3R and MC4R. Bremelanotide PT-141 has been in the system for several years now and Melanotan 2, a biologically available hormone, is the alternative of the synthetic version. The hormone is essential in stimulating the formation of melanin in epidermal cells of the skin via a process called melanogenesis. This is one of the most important biological processes because it helps avoid skin cancer and other similar conditions.
PT-141 peptide was patented in 1988 and is classified as a less potent form of bremelanotide. The patent had a specification on the peptide in terms of functionality, characteristics and efficacy. According to research, the best mode of administration is through inhalation. However, it could be administered in any other method that increases its bioavailability and efficacy on test organisms. According to research, the peptide accentuate the release of growth hormones by over fifty times. Since it has a better half life than the endogenous hormone, there is a possibility of better functionality when used in modern research.
The pt 141 peptide works via stimulation of specific melanocortin receptors for optimal functionality. The melanocyte-stimulating hormone has a significant influence on appetite, libido,and lipid metabolism. Various studies have indicated that PT-141 activates several MC1R and MC4R receptors to accentuate their activity. PT 141 was produced after numerous research on identifying molecules that will promote sunless tanning or a peptide which can stimulate natural tanning process without any chemical inclusion. Melanotan 2 has other effects apart from inducing tanning or converting eumelanin to melanin on the epidermal cells. In some recent medical journals, it is revealed that it can cause sexual arousal in women and erections in men.
It is important to understand that PT 141 can induce lordosis and can be a remedy for sexual dysfunction for both men and women. The mechanism of action is via activation of melanocortin receptors located in the central nervous system. These receptors are important in modulating and limiting the chances of developing ischemia. Moreover, more studies are being conducted on the pt 141 peptide on its activity as a smoothening agent. In this aspect, it can be applied to the vaginal walls where it will alleviate arousal disorders and other problems.
When you buy PT-141 peptide, it will allow you to conduct research on one of the best-touted aphrodisiacs in the world. It is observed that the peptide improves libido by acting on the CNS rather than the vascular system as many people had assumed. According to studies, the peptide makes the test subjects feel excited, a throbbing, tingling sensation as well as heightened sexual appeal and energy. The PT-141 bremelanotide is usually available in 10 mg vials which this is the industry standard. The 2mg version are those that can be utilized in small experimental research. Freeze-dried bremelanotide is durable and stable and the 10 mg vial is a huge quantity. According to research, that can offer up to 20 potent doses. PT-141 should be reconstituted using bacteriostatic water and used within 6-12 months. It is important that the vials are stored in refrigerated conditions between 2 and 8 degree Celsius. Moreover, the diluted preparation should be refrigerated for better results.
A dose of 0.25 mg to 0.5 mg is recommended for the initial attempt. However, studies revealed that the PT 141 peptide hits high activity at 1-2mg. After 4 hours, the activity of the peptide is at its peak and a gradual increase in dosage will bring about the desired effect without the need alleviate the ultimate problem. There are numerous forms of the peptide – nasal sprays, pre-mixed versions and pills, among others.
Bremelanotide PT 141 and Erectile Dysfunction
Penile erection is a complex psychological and physiological condition which results from the interactions of the highly specialized organ and the central nervous system. The activation of central nervous system melanocortin receptors though synthetic ligand or endogenous ligand may initiate a spontaneous erection. While the central nervous system may principally act on MC4 and MC3 receptors, there are conflicting postulates and findings on the receptor that causes erection because the role of MC3 receptor is not well understood. Novel research data showed that antagonism of the forebrain MC3R has a positive feedback on erection. Moreover, melanocortin agents interact with oxytocinergenic pathways at the spinal, brainstem or hypothalamic levels. Manipulation of MC receptors is the new method of dealing with erectile dysfunction. This may provide an alternative therapeutic approach to sexual dysfunctions. PT 141 is a super potent MC agonist and it is a carboxylate derivative of the Melanotan 2.
The melanocortin cortinergic system is important in mediating numerous complex and a wide array of physiological effects which include food intake regulation, salt regulation, skin pigmentation, penile erection, pain nerve regeneration and sexual behavior. The numerous effects occur via selective activation of 5-receptor subtypes which are unique for alternate posttranslational modification of the proopiomelanocortin gene or POMC gene. The receptor subtypes include alpha MSH, gamma MSH, beta MSH and ACTH. There is a high possibility for developing new compounds through the understanding of subtype receptors. The pro-erectile functionality of the melanocortinergenic compounds were discovered in the mid 20th century and studies have been since enhanced and regulated through activation of receptor subtypes.
Understanding PT 141 Efficacy and Potency
In the initial testing of the synthetic agent, for artificial tanning resulted in an eight-hour long erection which scientist believed to be one of the basic effects of MC receptors. There have been numerous studies focused on the possibility of understanding the effects of the melanocortinergic system on penile erection. PT 141 reviews have shown to have erection effects and a normal erection occurs when the central nervous system is flooded with the peptide. The supraspinal centers in the brain are responsible for integrating hormonal and sensory inputs which in turn are related to the parasympathetic and sympathetic centers which are important in regulating the sacral cord essential in regulating the vascular tone of penile tissues. The inhibition of sympathetic constriction and vasolidilatory parasympathetic increase blood to the penile area which causes an erection.
The neurotransmitter modulating the erection via nitric oxide release in non-cholinergic and non-androgenic nerves which activate cavernosal smooth muscle cells to guanylyl cyclase, the enhanced production of the cyclic nucleotide guanosine monophosphate and this results in cellular relaxation via calcium regulating channels and this activates ejaculation.
PT 141 for sale is available to research industries, clinics and scientists who want to identify new possibilities for the use of the peptide. Some studies have revealed that the peptide is 50 times more potent than Melanotan 2 and that it induces erections in male rats. These studies are still underway. It is imperative to keep the hormone clean before it is approved for human consumption. Moreover, the therapeutic window is a thousand fold. There are other expected effects which may include reduction in appetite, nausea, yawning and vomiting in some cases. A conclusive research showed that bremelanotide PT 141 would be more effective than its predecessor Melanotan 2. Previous studies have shown that melanocortin peptides have positive feedback mechanisms on doparminergic neurotransmission.
The main goal of the studies is to ascertain how PT 141 can be used in treating some conditions that would otherwise ruin lives of people. However, it is important to note that the peptide is still under research for its effectiveness, efficacy, potency and safety and has not been approved for human consumption. The PT 141 peptides stimulate specific molecular markers in the brain to bring about effects on MC receptors. Research showed that female mice that were under study showed sexual behavior once bremelanotide PT 141 was applied to the hypothalamic and limbic regions of their brains. This study revealed that the peptide stimulated a chemical referred to as MPOA leading to the activation of dopamine in the brain. Dopamine is a feel good hormone and when it is secreted into the system, it brings about a feel-good factor and accentuates sexual arousal.
Recent Research on PT 141
There are numerous research studies focused on determining the efficacy and potency of the PT 141 peptide. Researchers are looking at ways of utilizing the peptide to stimulate sunless tanning – an aspect that will combat skin cancer or melanoma. In addition, there were studies aimed at determining the role of PT 141 peptide in inducing or accentuating sexual behaviors. According to research done on mice, male and female mice were injected with a varying dose of PT 141 ranging from 0.5mg to 2mg. During the research, the mice were monitored closely and findings were recorded. Within two hours of administration, the male mice exhibited erections and lordosis and they began sexual solicitation behaviors. On the other hand, female mice showed reddening of sexual organs, solicitation behaviors and darting all signs of sexual arousal in rodents. It is imperative to note that they were in a controlled environment and each group was kept separately to avoid complications. Findings from this research indicated that PT 141 is effective in enhancing sexual-related and solicitation behaviors. However, the peptide’s safety and efficacy are not yet ascertained and therefore cannot be used on humans.
Peptides supplied in the market are solely for research purposes only. Depending on your study, you can alter the dosage and monitor test subjects for any change and behavior. Application of PT 141 on test subject varies depending on the test organisms. However, the most effective ways of administering the peptide are via oral, nasal cavity and intravenous administration. In a recent research, when the peptide is administered, it increases the blood pressure of the test subject. However, this is bound to further research to ascertain its functionality. PT 141 is touted as one of the best and most effective aphrodisiacs. All information from the research is not conclusive and further investigation has to be conducted to ascertain its efficacy.
The working mechanism of PT 141 is via increasing libido. It does this by acting on central nervous system which is unlike other peptides that work on the vascular system. The main target of this peptide is the brain arousal center and as per research, it increases sexual stimulation, prompting sexual related behaviors in test organisms. According to the research, there is a sudden increase in blood flow to the sexual organs as shown by research mice. PT 141 is currently under research for alleviating different conditions such as erectile dysfunctions, hemorrhagic shock and reperfusion injury. The objective of the study is to identify the effects of PT 141 in stimulating sexual arousal in both males and females.